Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes.Malignant transformation is associated with aberrant accumulation of repressive histone modifications, ACN such as polycomb mediated histone 3 lysine 27 (H3K27me3) resulting in a